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Late‐evening snack with branched‐chain amino acids improves liver function after radiofrequency ablation for hepatocellular carcinoma
Author(s) -
Morihara Daisuke,
Iwata Kaoru,
Hanano Takayuki,
Kunimoto Hideo,
Kuno Shizuka,
Fukunaga Atsushi,
Yotsumoto Kaoru,
Takata Kazuhide,
Tanaka Takashi,
Sakurai Kunitoshi,
Iwashita Hideyuki,
Ueda Shuichi,
Hirano Genryu,
Yokoyama Keiji,
Nakane Hidetoshi,
Nishizawa Shinya,
Yoshikane Makoto,
Anan Akira,
Takeyama Yasuaki,
Kakumitsu Shigeru,
Kitamura Yuji,
Sakamoto Masaharu,
Irie Makoto,
Shakado Satoshi,
Sohda Tetsuro,
Watanabe Hiroshi,
Sakisaka Shotaro
Publication year - 2012
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2012.00969.x
Subject(s) - hepatocellular carcinoma , medicine , radiofrequency ablation , liver function , gastroenterology , cirrhosis , morning , liver cancer , evening , glycemic , ablation , insulin , physics , astronomy
Aim: This prospective study was designed to examine whether consumption of a branched‐chain amino acid (BCAA)‐enriched nutrient mixture as a late‐evening snack (LES) helps maintain and/or improve liver functioning in liver cirrhosis (LC) patients who have undergone radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods: An equal number (10) of 30 LC patients who had undergone RFA for HCC was randomly assigned to a standard diet group (control) group, a morning BCAA (M‐BCAA) administration group, or a LES with BCAA (LES‐BCAA) administration group. Liver function testing was performed and Child–Pugh scores (CPS) calculated for each group to assess the improvement at 1, 4 and 12 weeks post‐RFA. Results: Compared to the control and M‐BCAA groups, the LES‐BCAA group experienced a rapid and significant improvement in albumin and total serum bilirubin levels and in CPS that began during the initial post‐RFA period. These results indicate that LES with BCAA supplementation significantly improved the CPS of the LES‐BCAA group at 4 and 12 weeks post‐RFA. Although no patients experienced serious adverse effects, two patients who had been diagnosed with diabetes mellitus before undergoing RFA required blood sugar management to improve glycemic control and one subject withdrew due to supplement‐induced vomiting. Conclusion: LES with BCAA supplementation significantly and rapidly improves liver functioning and CPS in LC patients who have undergone RFA for HCC. Control of blood sugar levels is necessary when calorie‐containing BCAA is administrated to LC patients with impaired glucose tolerance.