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Membrane recruitment of autophagy proteins in selective autophagy
Author(s) -
Morita Eiji,
Yoshimori Tamotsu
Publication year - 2012
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2011.00955.x
Subject(s) - autophagy , endoplasmic reticulum , autophagosome , microbiology and biotechnology , downregulation and upregulation , biology , unfolded protein response , gene , biochemistry , apoptosis
Autophagy is a stress response that is upregulated in response to signals such as starvation, growth factor deprivation, endoplasmic reticulum stress, and pathogen infection. Defects in this pathway are the underlying cause of a number of diseases, including metabolic aberrations, infectious diseases, and cancer, which are closely related to hepatic disorders. To date, more than 30 human ATG (autophagy) genes have been reported to regulate autophagosome formation. In this review, we summarize the current understanding of how ATG proteins behave during autophagosome formation in both non‐selective and selective autophagy.