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Hepatobiliary membrane transporters in primary biliary cirrhosis
Author(s) -
Takeyama Yasuaki,
Sakisaka Shotaro
Publication year - 2012
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2011.00912.x
Subject(s) - primary biliary cirrhosis , transporter , efflux , epithelial polarity , membrane transport , secretion , biliary cirrhosis , cirrhosis , membrane transport protein , chemistry , atp binding cassette transporter , organic cation transport proteins , medicine , biochemistry , membrane , disease , autoimmune disease , gene
The secretion of bile normally depends on the function of a number of membrane transport systems in hepatocytes and cholangiocytes. The transport of solutes from the blood to the bile is driven by transport systems in the plasma membrane of the basolateral and canalicular surfaces of the hepatocytes. In cholestatic animal models, the expression of hepatobiliary transporters changes in response to functional impairment of the efflux of bile salts and various organic anions. In recent years, several studies have led to an improved understanding of the function and regulation of hepatobiliary transport systems in patients with primary biliary cirrhosis (PBC). This review focuses on the adaptations in hepatobiliary transporters in PBC patients.