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Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice
Author(s) -
Wang Ting,
Takikawa Yasuhiro,
Satoh Takumi,
Yoshioka Yoshichika,
Kosaka Kunio,
Tatemichi Yoshinori,
Suzuki Kazuyuki
Publication year - 2011
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2010.00747.x
Subject(s) - medicine , endocrinology , steatosis , triglyceride , fatty liver , obesity , glucose tolerance test , chemistry , cholesterol , insulin resistance , disease
Aim: Carnosic acid (CA) inhibits adipogenesis in vitro . The present study evaluated the therapeutic effects of CA in ob/ob mice. Methods: The experimental animals were given a standard chow diet with or without CA for 5 weeks. Bodyweight gain and food intake were measured during this period. Magnetic resonance imaging analysis, histological examination, serum chemistry analysis and intraperitoneal glucose tolerance test (IPGTT) were all performed. Results: The mice fed CA experienced significant weight loss and reduced visceral adiposity, in addition to significantly reduced serum triglyceride (TG) and cholesterol levels. Importantly, CA had a dramatic effect on the liver by reducing the hepatic TG content, thus decreasing serum alanine aminotransferase levels. In addition, IPGTT revealed that CA significantly improved glucose tolerance. Conclusion: These data suggest that CA is a novel therapeutic agent for obesity‐related non‐alcoholic fatty liver disease.