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Serum HGF and TGF‐β1 levels after right portal vein embolization
Author(s) -
Hayashi Hiromitsu,
Beppu Toru,
Sugita Hiroki,
Masuda Toshiro,
Okabe Hirohisa,
Takamori Hiroshi,
Baba Hideo
Publication year - 2010
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2009.00599.x
Subject(s) - hepatocyte growth factor , medicine , transforming growth factor , portal vein embolization , computed tomographic , embolization , endocrinology , portal vein , gastroenterology , urology , computed tomography , radiology , surgery , hepatectomy , receptor , resection
Aim: The changes in the serum hepatocyte growth factor (HGF) and transforming growth factor (TGF)‐beta1 levels after portal vein embolization (PVE), and their clinical significance, remain unclear and we aimed to assess their relationship. Methods: The serum HGF and TGF‐beta1 levels were prospectively measured in 22 patients before and 1, 3, 5, 7, and 14 day after right PVE. Computed tomographic volumetry was performed before and at a mean of 26 ± 4 days after right PVE. Results: Three to four weeks after right PVE, the volume of embolized lobe significantly decreased from 704 ± 157 cm 3 before PVE to 539 ± 168 cm 3 after PVE ( P < 0.001). In contrast, the volume of nonembolized lobe significantly increased from 426 ± 142 cm 3 to 560 ± 165 cm 3 ( P < 0.001). The serum HGF level significantly increased on day 3 after PVE compared with the pretreatment level ( P = 0.005), while the serum TGF‐beta1 level significantly decreased and reached its lowest value on day 3 ( P = 0.002). Using Pearson's correlation analysis, we found that the serum HGF and TGF‐beta1 levels on day 14 negatively associated with the large hypertrophic response in the nonembolized lobe (HGF: r = −0.490, P = 0.021; TGF‐beta1: r = −0.473, P = 0.026). Conclusions: PVE induced an increase in the serum HGF level and reduced the serum TGF‐beta1 level. Measurement of serum HGF and TGF‐beta1 levels on day 14 after right PVE may be useful for assessment of the future liver hypertrophy in nonembolized lobe after right PVE.