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Matrine improves 17α‐ethinyl estradiol‐induced acute cholestasis in rats
Author(s) -
Zhao Ying,
Zhai Desheng,
He Hui,
Liu Junhua,
Li Tingting,
Chen Xijing,
Ji Hui
Publication year - 2009
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2009.00557.x
Subject(s) - bile salt export pump , cholestasis , glycocholic acid , medicine , ursodeoxycholic acid , bile acid , endocrinology , excretion , multidrug resistance associated protein 2 , taurocholic acid , chemistry , matrine , cholic acid , biochemistry , transporter , atp binding cassette transporter , gene , chromatography
Aim: To explore the effects of matrine (MT) on acute intrahepatic cholestasis induced by 17α‐ethinyl estradiol (EE) in rats. Methods: Acute intrahepatic cholestasis in rats were induced by EE, and the effects of MT on acute intrahepatic cholestasis were explored and compared with ursodeoxycholic acid (UDCA) by serum biochemical determination and bile excretion experiments. Results: The serum biochemical and bile biochemical results indicated that MT and UDCA had notable hepatoprotective effects by counteracting cholestasis induced by EE. The bile flow and the bile excretion of glycocholic acid (GC, a substrate of bile salt export pump [Bsep]), ketoprofen glucuronide (KPG) and rhodamine 123 (Rh123, a substrate of multidrug resistance protein 1 [MDR1]) decreased by EE, were significantly improved after administration of MT. Conclusion: MT exhibited potential protection against EE‐induced acute intrahepatic cholestasis.