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Hepatitis C virus kinetics during the first phase of pegylated interferon‐α‐2b with ribavirin therapy in patients with living donor liver transplantation
Author(s) -
Ichikawa Tatsuki,
Nakao Kazuhiko,
Miyaaki Hisamitsu,
Eguchi Susumu,
Takatsuki Mitsuhisa,
Fujimito Masumi,
Akiyama Motohisa,
Miuma Satoshi,
Ozawa Eisuke,
Shibata Hidetaka,
Takeshita Shigeyuki,
Kanematsu Takashi,
Eguchi Katsumi
Publication year - 2009
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2009.00524.x
Subject(s) - ribavirin , medicine , pegylated interferon , gastroenterology , hepatitis c virus , liver transplantation , titer , interferon , transplantation , hepatitis c , immunology , virus
Aim: To identify the problems of pegylated interferon (PEG IFN) with ribavirin therapy against hepatitis C virus (HCV) reinfection in living donor liver transplantation (LDLT) patients. HCV kinetics during the PEG IFN with ribavirin therapy were analyzed in LDLT patients, as well as in chronic hepatitis C (CHC) patients. Methods: The study included 80 consecutive HCV infected patients undergoing PEG IFN with ribavirin therapy (64 CHC and 16 LDLT patients) who attended the Nagasaki University Hospital for an initial visit between January 2005 and December 2007. Results: The sustained viral response (VR) rate of the CHC group (80%) was superior to the LDLT group (22%). The viral disappearance rate of the CHC group was also superior to the LDLT group, regardless of the HCV serotype. The HCV core antigen (cAg) titer under treatment in the LDLT group was more than that of the CHC group from day 0 to week 12. The HCV cAg decrease rate of the LDLT group on the first day of treatment was less than that of the CHC group. Conclusion: The HCV infection of a transplanted liver is more refractory to treatment than a non‐transplanted liver. The low reduction HCV cAg rate on day 1 is one of the problems of the combination therapy.