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Occurrence of hepatocellular carcinoma after hepatoblastoma resection in an adult with hepatitis C virus
Author(s) -
Masuda Toshiro,
Beppu Toru,
Horino Kei,
Komori Hiroyuki,
Hayashi Hiromitsu,
Okabe Hirohisa,
Ootao Ryuu,
Horlad Hasita,
Baba Yoshifumi,
Miyase Shiho,
Takamori Hiroshi,
Baba Hideo
Publication year - 2009
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2008.00471.x
Subject(s) - hepatoblastoma , hepatocellular carcinoma , medicine , cirrhosis , liver tumor , malignancy , hepatectomy , pathology , gastroenterology , resection , surgery
Hepatoblastoma is a rare malignancy in adults. It is often diagnosed after the appearance of symptoms, therefore, the tumor size tends to be larger. In patients with no indication for a hepatic resection, the prognosis of adult hepatoblastoma is quite poor. A 54‐year‐old man with hepatitis C virus‐associated liver cirrhosis was initially treated with a hepatic resection for a hepatic tumor, 3 cm in diameter. The tumor consisted of osteoid‐like and cartilaginous foci, myxomatous stroma, and poorly differentiated hepatocellular carcinomatous cells and was diagnosed as a mixed epithelial and mesenchymal hepatoblastoma. Two years after the first operation, multicentric hepatocellular carcinomas developed in the remnant liver and were successfully treated with a secondary hepatic resection combined with radio‐frequency ablation. The patient is now alive with no recurrence at 5 years after the initial hepatectomy. To the best of our knowledge, the primary hepatoblastoma was the smallest such tumor reported and this is the first report of a metachronous hepatoblastoma and hepatocellular carcinoma in an adult hepatitis patient.