Premium
Efficacy of platinum analogue for advanced hepatocellular carcinoma unresponsive to transcatheter arterial chemoembolization with epirubicin
Author(s) -
Kawamura Yusuke,
Ikeda Kenji,
Hirakawa Miharu,
Hosaka Tetsuya,
Kobayashi Masahiro,
Saitoh Satoshi,
Yatsuji Hiromi,
Sezaki Hitomi,
Akuta Norio,
Suzuki Fumitaka,
Suzuki Yoshiyuki,
Arase Yasuji,
Kumada Hiromitsu
Publication year - 2009
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2008.00466.x
Subject(s) - epirubicin , medicine , hepatocellular carcinoma , transcatheter arterial chemoembolization , chemotherapy , progressive disease , arterial embolization , retrospective cohort study , gastroenterology , embolization , radiology , surgery , cyclophosphamide
Aim: Hepatocellular carcinoma (HCC) often shows resistance to transcatheter arterial chemoembolization (TACE). Such patients often have a poor prognosis and are unresponsive to other forms of therapy. The aim of this retrospective study was to determine the response to TACE using platinum analogues in patients deemed resistant to TACE using epirubicin. Methods: We studied 152 consecutive patients with advanced HCC resistant to TACE using epirubicin. All cases were treated with platinum analogue using transcatheter arterial chemotherapy with or without embolization. Results: Computed tomography at 3 months after therapy showed complete response (CR) in 6 patients (4.0%), partial response (PR) in 28 (18%), stable disease (SD) in 35 (23%), and progressive disease (PD) in 83 (55%). The cumulative survival rates for PR/CR patients who received platinum analogue‐transcatheter arterial chemotherapy with or without embolization (81.8% at first year, 53.9% at second year, and 33.1% at third year) were significantly higher than those of SD/PD patients (36.6%, 17.5% and 7.4%, respectively) ( P < 0.001). The 50% survival period was extended almost 1.4 year in PR/CR patients who received platinum analogue‐transcatheter arterial chemotherapy with or without embolization. Conclusion: Our retrospective study is the first to report the efficacy of platinum analogues for advanced HCC unresponsive to TACE using epirubicin.