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Gene expression profiling of non‐alcoholic steatohepatitis using gene set enrichment analysis
Author(s) -
Yoneda Masato,
Endo Hiroki,
Mawatari Hironori,
Nozaki Yuichi,
Fujita Koji,
Akiyama Tomoyuki,
Higurashi Takuma,
Uchiyama Takashi,
Yoneda Kyoko,
Takahashi Hirokazu,
Kirikoshi Hiroyuki,
Inamori Masahiko,
Abe Yasunobu,
Kubota Kensuke,
Saito Satoru,
Kobayashi Noritoshi,
Yamaguchi Naotaka,
Maeyama Shiro,
Yamamoto Shogo,
Tsutsumi Shuichi,
Aburatani Hiroyuki,
Wada Koichiro,
Hotta Kikuko,
Nakajima Atsushi
Publication year - 2008
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2008.00399.x
Subject(s) - steatohepatitis , gene expression profiling , dna microarray , fatty liver , gene , gene expression , biology , microarray , computational biology , cirrhosis , bioinformatics , genetics , disease , medicine
Non-alcoholic steatohepatitis (NASH) is a subset of non-alcoholic fatty liver disease (NAFLD) and sometimes progresses to cirrhosis and liver failure. In this study we analyzed the expression profile of genes and biological pathways involved in NASH in comparison with non-NASH by gene set enrichment analysis (GSEA) employing a DNA microarray technique.