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Hepatocyte steatosis in HCV patients promotes fibrosis by enhancing TGF‐β liver expression
Author(s) -
Gabriel Andrzej,
Ziólkowski Adam,
Radlowski Pawel,
Tomaszek Krzysztof,
Dziambor Andrzej
Publication year - 2008
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2007.00258.x
Subject(s) - steatosis , fibrosis , medicine , stage (stratigraphy) , gastroenterology , fatty liver , hepatocyte , hepatitis c , pathology , biology , disease , paleontology , biochemistry , in vitro
Aim: The objective of this study was to examine the relationship between TGF‐β expression in steatotic liver and the stage and yearly progression rate of fibrosis in chronic hepatitis C (CHC) patients. Methods: We examined 44 CHC fatty liver patients, using 76 non‐steatotic CHC patients as controls. The stage of hepatic fibrosis was assessed on a score scale. TGF‐β expression was determined with the use of monoclonal serum and the ABC three‐step method. Results: We demonstrated a positive correlation of steatosis with the stage of fibrosis ( P < 0.05). No relationship of thiskind was found with the yearly progression rate of fibrosis ( P > 0.09). In steatotic biopsies, TGF‐β expression index in portal spaces and lobules was found to be higher as compared to TGF‐β expression in biopsies without steatosis ( P < 0.05). Conclusion: In CHC patients steatosis induces the development of fibrosis by elevating the hepatic expression of TGF‐β.