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Autoimmunity and HIV/simian immunodeficiency virus infection: A two edged sword
Author(s) -
Ansari Aftab A.,
Pattanapanyasat Kovit,
Pereira Lara E.
Publication year - 2007
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2007.00225.x
Subject(s) - sword , simian immunodeficiency virus , human immunodeficiency virus (hiv) , virology , autoimmunity , simian , immunodeficiency , immunology , medicine , virus , immune system , computer science , world wide web
The purpose of this review is to provide an overview of the spectrum of autoimmune responses that we have so far characterized in the simian immunodeficiency virus (SIV)‐infected disease susceptible rhesus macaques, the potential role of the lymphopenic state for the generation of the autoimmune response and the important new finding that such autoimmune response in fact can serve to provide both clinical benefit and clinical disease depending on the stage of the disease and the nature of the host proteins that are recognized during this process.