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Diagnostic discrepancy of early hepatocellular carcinoma between Japan and West
Author(s) -
Kojiro Masamichi
Publication year - 2007
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2007.00174.x
Subject(s) - hepatocellular carcinoma , medicine , pathology , stromal cell
The diagnoses for a range of hepatocellular neoplastic lesions amongst Japanese and Western pathologists show a striking lack of consistency, especially in distinguishing dysplastic nodules (DN) from very well‐differentiated hepatocellular carcinomas (HCC). Namely, very well‐differentiated HCC showing a vaguely nodular appearance diagnosed by Japanese pathologists tends to be diagnosed as high‐grade DN by Western pathologists. Both Japanese and Western pathologists agreed that “stromal invasion”, which is tumor cell invasion into the intra‐tumoral portal tracts, is considered the most helpful morphologic clue to distinguish high‐grade DN from well‐differentiated HCC.