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Japanese case of hepatitis B virus genotypes C/D hybrid
Author(s) -
Yano Yoshihiko,
Truong Bui X.,
Seo Yasushi,
Kato Hirotaka,
Miki Akira,
Tanaka Yasuhito,
Mizokami Masashi,
Kagawa Ayako,
Miyazaki Hiroyuki,
Kasuga Masato,
Azuma Takeshi,
Hayashi Yoshitake
Publication year - 2007
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2007.00161.x
Subject(s) - genotype , virology , phylogenetic tree , hepatitis b virus , strain (injury) , biology , recombinant dna , sequence analysis , whole genome sequencing , genome , hepatitis c virus , breakpoint , virus , gene , medicine , genetics , chromosomal translocation , anatomy
Hepatitis B virus (HBV) is classified into eight genotypes based on complete genome sequence. Each genotype is related to geographic distribution and race. In Japan, most of the genotypes are B and C. In the present study, we report the first Japanese strain of HBV having a recombination between genotypes C and D. A 30‐year‐old woman was admitted to Kobe Medical Center because of liver dysfunction. She was diagnosed with spontaneous reactivation of chronic hepatitis B. She had no history of blood transfusion and her parents were negative for HBV. The phylogenetic analysis based on the complete genome sequences revealed that this strain was classified into genotype C, whereas the analysis based on S gene sequence showed that this strain was genotype D. By using a SimPlot program, this strain was confirmed as a recombinant strain between genotypes C and D. Compared with previous recombinant strains in China, the breakpoint was the same and the difference was only 0.8% of the complete genome sequence. It was unclear whether or not this strain was transmitted from China, but the recombinant strains and intergenotypes of HBV have already existed in Japan.