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Does l ‐carnitine have any effect on cold preservation injury of non‐fatty liver in the University of Wisconsin solution?
Author(s) -
Coskun Abdurrahman,
Gunal Omer,
Sahin Ibrahim,
Aslaner Arif,
Yildirim Umran,
Yavuz Ozlem
Publication year - 2007
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2007.00088.x
Subject(s) - viaspan , carnitine , food science , chemistry , medicine , biochemistry , transplantation
Aim: To evaluate the protective effect of l ‐carnitine on liver tissue preserved in University of Wisconsin (UW) solution. Methods: Twenty Wistar Albino rats were divided into two groups, a control (UW) group and a UW plus l ‐carnitine group. Retrieved liver grafts were preserved in UW and UW plus l ‐carnitine solutions at +4°C. Preservation solution samples were assessed at 2, 24, 36, and 48 h to measure alanine aminotransferase and acid phosphatase activity. Tissue injury was scored on paraffin sections. Results: No micro or macrovacuolar fat droplets were observed in the tissue slices. l ‐Carnitine effectively decreased enzyme release when added to UW solution ( P < 0.05). Conclusion: In addition to fatty liver, l ‐carnitine might be a metabolic adjunct in preservation solutions for non‐fatty liver within UW solution.