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A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation
Author(s) -
Takikawa Yasuhiro,
Yasumi Yuki,
Sato Akihiro,
Endo Ryujin,
Suzuki Kazuyuki,
Mori Yasuki,
Akasaka Hidetoshi,
Miura Yasuhiro,
Sawai Takashi,
Okamoto Hiroaki
Publication year - 2007
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2007.00021.x
Subject(s) - medicine , cytomegalovirus , cholestasis , immunology , eosinophilia , hypersensitivity reaction , hepatitis , drug , virology , virus , gastroenterology , viral disease , herpesviridae , pharmacology
A 65‐year‐old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction.