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Course and Severity of Postpartum Metritis Cases Following Antibiotic and PGF 2 α Administration in Postpartum Metritis Cows Infected with BoHV‐4
Author(s) -
Nak Y.,
Dagalp S. B.,
Cetin C.,
Nak D.,
Alkan F.,
Borum E.,
Tuna B.
Publication year - 2011
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/j.1865-1682.2010.01174.x
Subject(s) - metritis , oxytetracycline , medicine , ceftiofur , antibiotics , endometritis , vaginal discharge , amoxicillin , veterinary medicine , gynecology , microbiology and biotechnology , antibiotic resistance , ice calving , pregnancy , biology , lactation , genetics
Summary Forty cows between day 1 and day 21 post‐calving were examined for the presence of postpartum metritis in a dairy herd that had recently experienced an increase in metritis and that had previously tested positive against bovine herpes virus 4 (BoHV‐4) by various methods. Antibodies against BoHV‐4 were detected in sera from 15 of 22 cows. For the virological study, uterine swab samples of 22 cows with metritis were used and tested for BoHV‐4 using polymerase chain reaction (PCR), virus isolation (VI), and immunofluorescence techniques. Twenty‐two point seven per cent (5/22) of the vaginal discharge samples obtained from cows with metritis were found positive for BoHV‐4 DNA by PCR. All of these samples were also positive in VI and/or immune fluorescence assay (IF). Swab samples were also tested for bacteria. Empirical therapy with a broad spectrum antibiotic (oxytetracycline) was administrated, pending culture and antibiotic sensitivity result. All cows with puerperal metritis or clinical metritis (CM) were treated with intra‐uterine (i.u.) administration of oxytetracycline and with intramuscular (i.m.) injections of dinoprost tromethamine (PGF 2 α) for three consecutive days. Concurrently, with the administration of oxytetracycline and PGF 2 α, cows with a rectal temperature >39.5°C received an additional treatment with oxytetracycline (i.m) for three consecutive days. According to the antibiotic test result, on day 3 after the last oxytetracycline and PGF 2 α administrations, all cows were treated with a combination of amoxicillin and clavulanic acid (i.u.) for three consecutive days. All cows with metritis and that were positive for BoHV‐4 recovered clinically after the administration of antibiotic and PGF 2 α. In conclusion, postpartum metritis cases in cows infected BoHV‐4 recovered clinically following early diagnosis and prolonged treatments with a combination of antibiotics and PGF 2 α.