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Autophagy and the Immune Response to TB
Author(s) -
Harris J.,
Hope J. C.,
Lavelle E. C.
Publication year - 2009
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/j.1865-1682.2009.01069.x
Subject(s) - autophagy , phagosome , inflammasome , immune system , microbiology and biotechnology , biology , antigen presentation , acquired immune system , innate immune system , pathogen , organelle , antigen , immunology , inflammation , intracellular , t cell , biochemistry , apoptosis
Summary Autophagy is a homeostatic mechanism for the catabolism of cytosolic constituents, including organelles, in times of stress and nutrient deprivation. In addition, autophagy has been linked to innate and adaptive immune responses to numerous infectious microorganisms, including mycobacteria. This review explores the role of autophagy in the responses of antigen‐presenting cells to mycobacteria, including links with phagosome maturation, inflammasome activation and antigen presentation. In addition, the modulation of autophagy by cytokines and pathogen‐derived stimuli is discussed.