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Frequencies of PRNP Gene Polymorphisms in Vietnamese Dairy Cattle for Potential Association with BSE
Author(s) -
Muramatsu Y.,
Sakemi Y.,
Horiuchi M.,
Ogawa T.,
Suzuki K.,
Kanameda M.,
Hanh T. T.,
Tamura Y.
Publication year - 2008
Publication title -
zoonoses and public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.87
H-Index - 65
eISSN - 1863-2378
pISSN - 1863-1959
DOI - 10.1111/j.1863-2378.2008.01119.x
Subject(s) - indel , prnp , biology , genotype , bovine spongiform encephalopathy , genetics , allele , vietnamese , polymorphism (computer science) , dairy cattle , allele frequency , gene , single nucleotide polymorphism , medicine , prion protein , linguistics , philosophy , disease
Summary Since 2004, significant associations between bovine spongiform encephalopathy (BSE) susceptibility in cattle and frequencies of insertion/deletion (ins/del; indel) polymorphisms within the bovine prion protein gene ( PRNP ) have been reported. In this study, we investigated the frequencies of indel polymorphisms within two variable sites, a 23‐bp indel polymorphism in the promoter region (23indel) and a 12‐bp indel polymorphism in intron 1 region (12indel), in the PRNP in 206 Vietnamese dairy cattle and seven Japanese BSE‐affected cattle. In Vietnamese dairy cattle, the frequency distributions of del allele and del/del genotypic polymorphisms in the 23indel site, which are thought to be associated with BSE susceptibility, were significantly higher, whereas the frequencies of del allelic and del/del genotypic polymorphisms in the 12indel site, which have been reported to confer BSE susceptibility, were significantly lower. We have provided evidence that Vietnamese dairy cattle have a unique genetic background in the PRNP gene in comparison with cattle or sires previously reported in other countries.