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A case of chronic severe neutropenia: Oral findings and consequences of short‐term granulocyte colony‐stimulating factor treatment
Author(s) -
Hastürk Hatice,
Tezcan Ilhan,
Yel Leman,
Ersoy Fügen,
Sanal Özden,
Yamalik Nermin,
Berker Ezel
Publication year - 1998
Publication title -
australian dental journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 71
eISSN - 1834-7819
pISSN - 0045-0421
DOI - 10.1111/j.1834-7819.1998.tb00144.x
Subject(s) - medicine , neutropenia , granulocyte colony stimulating factor , periodontitis , dental alveolus , congenital neutropenia , granulocyte , absolute neutrophil count , cyclic neutropenia , gastroenterology , chemotherapy , dentistry
Neutropenia is an absolute decrease in the number of circulating neutrophils in the blood which results in susceptibility to severe pyogenic infections. Various oral findings such as periodontitis, alveolar bone loss and ulceration may be seen in neutropenic patients. A case is presented of a 6 year old girl with chronic, probably congenital, severe neutropenia with frequent respiratory tract infections, recurrent oral ulcerations and significant periodontal breakdown resembling prepubertal periodontitis. She was given granulocyte‐colony stimulating factor (G‐CSF) treatment which resulted in an increase in granulocyte count within two weeks and resolution of the neutropenic ulceration. It is suggested that G‐CSF together with dental care regimens is a promising treatment model in chronic severe neutropenia cases presenting with oral manifestations.