Open AccessThe Potential Role of Factor VIIa in Transfusion Medicine
Author(s) -
Hoffman Maureane
Publication year - 2003
Publication title -
transfusion alternatives in transfusion medicine
Language(s) - English
Resource type - Journals
eISSN - 1778-428X
pISSN - 1295-9022
DOI - 10.1111/j.1778-428x.2003.tb00096.x
Subject(s) - medicine , hemostasis , recombinant factor viia , hemostatic agent , platelet , intensive care medicine , surgery , immunology
SUMMARY Therapy with high doses of recombinant factor VIIa (rFVIIa) is effective in promoting hemostasis in hemophiliacs. There is also some evidence to support the idea that this agent can enhance hemostasis in patients with platelet function defects, thrombocytopenia and liver failure, as well as in persons without a preexisting bleeding disorder. Because of this hemostatic effect in a wide range of clinical settings, it is possible that rFVIIa could serve as a substitute or supplement to the transfusion of blood products.