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Mechanisms of genetic instability revealed by analysis of yeast spindle pole body duplication
Author(s) -
Chial Heidi J,
Winey Mark
Publication year - 1999
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1999.tb01099.x
Subject(s) - centrosome , spindle pole body , biology , multipolar spindles , spindle apparatus , chromosome instability , microbiology and biotechnology , gene duplication , mitosis , genetics , saccharomyces cerevisiae , microtubule organizing center , chromosome segregation , genome instability , mitotic crossover , budding yeast , aneuploidy , microtubule , yeast , chromosome , cell division , cell , gene , cell cycle , dna , dna damage
Aneuploidy and polyploidy are commonly observed in transformed cells. These states arise from failures during mitotic chromosome segregation, some of which can be traced to defects in the function or duplication of the centrosome. The centrosome is the organizing center for the mitotic spindle, and the equivalent organelle in the budding yeast, Saccharomyces cerevisiae , is the spindle pole body. We review how defects in spindle pole body duplication or function lead to genetic instability in yeast. There are several well documented instances of genetic instability in yeast that can be traced to the spindle pole body, all of which serve as models for genetic instability in transformed cells.