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Restoration of dysgenic murine (mdg) myotube contraction after addition of Schwann cells from normal mice in vitro
Author(s) -
Courbin Pierre,
Thi Ahn,
Ressouches Annie,
Dussartre Christian,
Powell Jeanne Anne,
Koenig Jeanine
Publication year - 1989
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1989.tb00882.x
Subject(s) - biology , myogenesis , contraction (grammar) , in vitro , ultrastructure , microbiology and biotechnology , muscle contraction , myocyte , medicine , ratón , endocrinology , anatomy , biochemistry
Muscular dysgenesis in mutant mice is characterised by failure of excitation‐contraction (E‐C) coupling and consequent loss of skeletal muscle contraction. Contractile activity is restored in vitro by the addition of normal mice cells (11) (18) (7). In the present study we show a new model: contraction and ultrastructural organization of dysgenic myotubes are restored by coculture with Schwann cells from normal mice.