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Farnesylacetone, a sesquiterpenic hormone of crustacea, inhibits electron transport in isolated rat liver mitochondria
Author(s) -
Dupont Jacques,
Rodes JeanFrançois,
BerreurBonnenfant Josette,
Carre MarieClaude,
Tekitek Ali,
Berreur Paul
Publication year - 1989
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1989.tb00856.x
Subject(s) - biology , electron transport chain , carcinus maenas , mitochondrion , biochemistry , electron transfer , nadh dehydrogenase , reductase , enzyme , electron acceptor , succinate dehydrogenase , respiration , crustacean , protein subunit , anatomy , chemistry , decapoda , ecology , photochemistry , gene
Farnesylacetone (C18 H30 0) is a male hormone extracted from the androgenic gland of crab, Carcinus maenas . Appropriate enzymatic assays, as well as spectrophotometric studies, indicate that micromolar concentrations of farnesylacetone interact with the electron transport pathway of rat liver mitochondria. By the use of artificial electron donors and electron acceptors, it is shown that farnesylacetone immediately inhibits the electron transfer within complex I (NADH ubiquinone reductase activity) and complex II (succinate ubiquinone reductase activity). It is proposed that farnesylacetone could interact with these two complexes of the respiratory chain at the level of the iron‐sulfur centers implicated in the dehydrogenase activities. These observations are compared with the results obtained with terpenic molecules which interact with mitochondrial respiration.