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Localization of functional centers on the prokaryotic ribosome: immuno‐electron microscopy approach
Author(s) -
Spirin Alexander S.,
Vasiliev Victor D.
Publication year - 1989
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1989.tb00838.x
Subject(s) - peptidyl transferase , ribosome , biology , translation (biology) , escherichia coli , electron microscope , transfer rna , a site , ribosomal binding site , microbiology and biotechnology , biophysics , binding site , computational biology , messenger rna , biochemistry , physics , rna , gene , optics
Immuno‐electron microscopy studies on the morphology of the Escherichia coli ribosome and the topography of its functional centers are summarized. A three‐dimensional model of the ribosome with indications of the mRNA‐binding site, the peptidyl‐transferase center, the EF‐Tu and EF‐G‐binding sites and the tRNA‐binding sites in given. Thus, the mutual arrangement of the centers corresponding to the main functional activities of the ribosome during the process of translation is presented.