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Cell cycle‐specific variation of intercellular plasminogen activator activity in cultured human alveolar epithelial carcinoma and rat hepatoma cells
Author(s) -
Orfanoudakis Georges,
Zaoui Driss,
Befort JeanJacques,
Bieth Joseph G.
Publication year - 1989
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1989.tb00802.x
Subject(s) - biology , plasminogen activator , a549 cell , intracellular , activator (genetics) , cell culture , cell cycle , cell , microbiology and biotechnology , carcinoma , cell division , endocrinology , gene , biochemistry , genetics
Plasminogen activator activity was demonstrated in two carcinoma cell lines: A549 cells derived from a human alveolar epithelial carcinoma; and ZHC cells derived from a rat hepotoma. Beoth cells had intracellular plasminogen activator activity throughout their cell cycles and in each case this activity reached a maxumum. For A549 cells the maximal activity took place either during the G 2 phase or in the course of the S to G 2 transition, suggesting that plasminogen activator might play a role in cell division. For ZHC cells, the maximal activity occurred at the start of the S phase, suggesting that in these cells plasminogen activator might be involved in DNA replication.