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Heat shock stress is deleterious to CNS cultured neurons microinjected with anti‐HSP70 antibodies
Author(s) -
Khan Naim A.,
Sotelo Julio
Publication year - 1989
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1989.tb00790.x
Subject(s) - biology , hsp70 , antibody , neurite , in vitro , shock (circulatory) , population , microbiology and biotechnology , heat shock protein , immunology , medicine , biochemistry , demography , sociology , gene
CNS cultured neurons microinjected with anti‐mouse immunoglobulin or anti‐hsp70 antibodies and cultured at 37°C remained healthy while those injected with anti‐hsp70 antibodies, exposed to 50°C for 15 min and returned to 37°C exhibited deleterious effects i.e. lesser interconnecting neurites and poor neuronal population. This shows that heat shock stress affects the survival of neurons in vitro .