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In vitro effects of calcium phosphate biomaterials on fibroblastic cell behavior
Author(s) -
Gregoire M.,
Orly I.,
Kerebel L. M.,
Kerebel B.
Publication year - 1987
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1987.tb00538.x
Subject(s) - fibroblast , calcium , phagocytosis , biology , in vitro , cell , intracellular , thymidine , microbiology and biotechnology , calcium in biology , dna synthesis , cell growth , biophysics , biochemistry , materials science , metallurgy
The effect of synthetic granular hydroxyapatite (HAP) on cultured fibroblastic cells (L929, human bone and gingiva cells) was studied. Phagocytosis of HAP particles and resulting morphological cell changes were demonstrated by microscopic examinations. Cell counts and [3H]thymidine uptake indicated significant increases in cell proliferation and DNA synthesis. These results could account for some of the alterations of the fibroblast behavior induced by changes in intracellular levels of calcium ions released from the material.