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Phorbol esters as signal transducers and tumor promoters
Author(s) -
Castagna M.
Publication year - 1987
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1987.tb00513.x
Subject(s) - biology , signal transduction , protein kinase c , microbiology and biotechnology , carcinogenesis , phorbol ester , transduction (biophysics) , extracellular , promoter , biochemistry , gene expression , gene
Extracellular ligands transfer information into the cell through various signaling pathways which operate in an integrated way. Oncogene proteins and tumor promoters cooperate to constitutively turn on the signaling pathways and lead to irreversible cell activation. The evidence that supports this concept is reviewed, with emphasis on the role of phorbol esters and protein kinase C in signal transduction and oncogenesis.