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Effects of antineoplastic agents on the cell cycle progression
Author(s) -
Charcosset J. Y.
Publication year - 1986
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1986.tb00497.x
Subject(s) - biology , cell cycle , dna , cell cycle progression , dna synthesis , microbiology and biotechnology , cell , dna damage , antineoplastic drugs , cell growth , cancer research , pharmacology , genetics
Almost all antineoplastic drugs are able to delay—or block—cells in a particular phase of the cell cycle. Few clinically active drugs seem to interact with the G1‐states where cell growth can be arrested, although new compounds could be of interest with this respect. In contrast, most antineoplastic agents interact with DNA and/or DNA metabolism and have been shown to provoke a delay in G2. This could be the consequence of the DNA damage or of interference with controls which take place within the G2 phase.