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Secretory cell activity in the hamster seminal vesicle following castration. A morphometric ultrastructural study
Author(s) -
Mata L. R.,
DavidFerreira J. F.
Publication year - 1985
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1985.tb00364.x
Subject(s) - hamster , biology , endoplasmic reticulum , golgi apparatus , secretory vesicle , seminal vesicle , exocytosis , ultrastructure , secretion , secretory protein , microbiology and biotechnology , epithelium , vesicle , castration , medicine , endocrinology , granule (geology) , mesocricetus , extracellular vesicle , prostate , anatomy , hormone , microvesicles , biochemistry , microrna , cancer , membrane , genetics , paleontology , gene
The ultrastructure of hamster seminal vesicle epithelium was studied 7, 14, 21 and 28 days after castration using a stereological approach. The results show that castration promotes epithelial reorganization, mainly characterized by reduced epithelial cell size and number, decreased rough endoplasmic reticulum and Golgi complex, increased lysosomes and lipid droplets, increased apical secretory granule size and number, and increased intracellular secretory products per average epithelial cell. It is concluded that after testosterone withdrawal the secretory activity of hamster seminal vesicle epithelial cells, although reduced, is not abolished, and that exocytosis is relatively more reduced than secretory protein production. We suggest that an extracellular androgen source is responsible for secretory activity not being lost in the epithelial cells of castrated hamster seminal vesicle.