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Some biochemical observations on gluconeogenesis from propionate in hepatocytes isolated from normal and biotin‐deficients rats
Author(s) -
Djabal A.,
Mangeot M.,
Cherruau B.,
Lemonnier A.
Publication year - 1985
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1985.tb00355.x
Subject(s) - gluconeogenesis , propionate , biotin , biology , medicine , endocrinology , malonate , biochemistry , glucagon , metabolism , citric acid cycle , insulin
Propionate and pyruvate added to isolated normal and biotin‐deficient adult rat hepatocytes increase the production of glucose. This production decreases about 30% on biotin deficiency. Malonate inhibits gluconeogenesis from propionate showing the metabolic transformation of propionyl‐CoA via the Krebs cycle. Neither glucagon nor dibutyryl‐cyclic AMP significantly stimulate gluconeogenesis.