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Relationship between growth inhibition and mitochondrial function in petite‐negative yeasts. II. Effects of central nervous system drugs upon pathogenic and non‐pathogenic Candida species
Author(s) -
Marmiroli N.,
Tedeschi F.,
Sabatini M. A.,
Truzzi G.,
Ferrari C.,
Puglisi P. P.
Publication year - 1985
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1111/j.1768-322x.1985.tb00354.x
Subject(s) - biology , candida albicans , yeast , chlorpromazine , microbiology and biotechnology , function (biology) , mitochondrion , fungus , corpus albicans , biochemistry , botany , pharmacology
Six nervous system drugs which inhibited vegetative reproduction of S. cerevisiae arrested also mitotic division of C. utilis, C. albicans and C. tropicalis. Chlorpromazine and chlorpheniramine which proved to be the most effective, affected respiration and cytochrome biosynthesis. Electrophoretic bands with MW congruent to 100 K were faint in silver‐stained electrophoregrams of proteins from cells grown in the presence of a sub‐inhibitory concentration of chlorpromazine.