Open AccessRoles of EBUS‐TBNA in non–small cell lung cancer
Author(s) -
Chung FuTsai,
Kuo ChihHsi,
Chen HaoCheng,
Feng PoHao,
Lin ShuMin,
Yu ChihTen,
Liu ChienYing,
Wang ChihWei,
Kuo HanPin
Publication year - 2012
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/j.1759-7714.2011.00093.x
Subject(s) - medicine , lung cancer , malignancy , radiology , predictive value , lung cancer staging , endobronchial ultrasound , oncology , mediastinoscopy
Background: Endobronchial ultrasound‐guided transbronchial aspiration (EBUS‐TBNA) has the potential to improve nodal diagnosis and staging in non–small cell lung cancer (NSCLC). This study was performed to explore the roles of EBUS‐TBNA in NSCLC. Methods: From 2007 to 2009, 164 NSCLC patients were examined by EBUS‐TBNA. The patients were divided into a diagnosis group (n = 64) and a staging group (n = 100). Results: For all patients, the diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 92.3%, 100%, 100%, 88.2%, and 95.1%, respectively. In the diagnosis group, the diagnostic sensitivity, specificity, PPV, NPV, and accuracy were 89.7%, 100%, 100%, 86.2%, and 94.4%, respectively. Thirty five patients (54.7%) positive for malignancy as determined by EBUS‐TBNA avoided surgery. In the staging group, the diagnostic sensitivity, specificity, PPV, NPV, accuracy, and surgery avoidance rate were 93.8%, 100%, 100%, 89.7%, 96%, and 61%, respectively. Conclusions: EBUS‐TBNA is a feasible and effective tool for NSCLC diagnosis and staging that also reduces surgery rates. Patients with NSCLC should initially undergo the less invasive EBUS‐TBNA procedure for diagnosis and staging of NSCLC. However, negative findings must be confirmed by surgery.