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Roles of two non‐structural viral proteins in virus‐induced demyelination
Author(s) -
Himeda Toshiki,
Ohara Yoshiro
Publication year - 2011
Publication title -
clinical and experimental neuroimmunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.297
H-Index - 15
ISSN - 1759-1961
DOI - 10.1111/j.1759-1961.2011.00021.x
Subject(s) - multiple sclerosis , demyelinating disease , virus , virology , encephalomyelitis , persistence (discontinuity) , biology , pathological , disease , immunology , medicine , pathology , geotechnical engineering , engineering
Theiler’s original (TO) subgroup strains of Theiler’s murine encephalomyelitis virus (TMEV) cause a milder polioencephalomyelitis followed by virus persistence and demyelination in the spinal cords of mice. TMEV‐induced demyelination is the representative of virus‐induced demyelination and serves as an excellent animal model for multiple sclerosis, because of the resembling pathological features. Two non‐structural viral proteins, leader (L) and L*, are reported to play an important role in TMEV biological activities. The present review will describe their properties, biological activities and how those proteins regulate TMEV‐persistence, which induces the demyelinating disease. (Clin. Exp. Neuroimmunol. doi: 10.1111/j.1759‐1961.2011.00021.x, September 2011)