Open AccessThe use of bone morphogenetic protein 7 in fracture non‐unions
Author(s) -
O'hEireamhoin Sven,
Quinlan John F,
Rourke Kieran O
Publication year - 2011
Publication title -
orthopaedic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 23
eISSN - 1757-7861
pISSN - 1757-7853
DOI - 10.1111/j.1757-7861.2010.00119.x
Subject(s) - bone morphogenetic protein , bone morphogenetic protein 5 , fracture (geology) , bone morphogenetic protein 7 , bone morphogenetic protein 2 , bone healing , medicine , orthodontics , anatomy , geology , biology , geotechnical engineering , biochemistry , gene , in vitro
Objective: To assess the rate of clinical and radiological union with the use of bone morphogenetic protein 7 (BMP‐7) in a range of fractures. Methods: This case series retrospectively reviews a series of 16 fracture non‐unions in 13 patients. These patients were treated with the commercially available BMP‐7. Time to radiological and clinical union was assessed by serial out‐patient follow‐up. Results: At nine months post‐surgery in which BMP‐7 was added, 12 of 16 non‐unions had achieved clinical and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 ± 1.6 months after the application of BMP‐7. Conclusion: The use of the osteo‐inductive agent, BMP‐7 results in good clinical and radiological outcomes which are not restricted to tibial non‐unions.