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Real‐Time Monitoring of Blood Flow and Intravesical Pressure in the Rat Bladder
Author(s) -
SAITO Motoaki,
OHMASA Fumiya,
TSOUNAPI Panagiota,
INOUE Seiya,
KINOSHITA Yukako,
DIMITRIADIS Fotios,
SATOH Keisuke
Publication year - 2011
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/j.1757-5672.2011.00094.x
Subject(s) - urination , blood flow , medicine , urology , reflex , blood pressure , anesthesia , urinary system
Objectives: Because there is little information available about blood flow in the voiding cycle of the bladder, we performed a study in which we simultaneously monitored blood flow and intravesical pressure during the micturition cycle in a rat model. Methods: Approximately 300 g male Wistar rats were used in this study. Cystometric studies were performed according to our previous report, and simultaneously blood flow was monitored. Results: Before the micturition reflex occurred, a significant increase in bladder blood flow was observed, and this increased blood flow continued during the micturition reflex. Under the maximum contraction pressure, blood flow rapidly decreased (within 10% compared to the max level). This low level of blood flow continued for more than half a minute. Conclusion: Our data indicated that the blood flow in the bladder was dynamically changed during voiding. This technique may represent a strong tool to investigate bladder function under drug administrations and/or pathophysiological conditions.