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Significance of Nitric Oxide and its Modulation Mechanisms in Micturition Disorders
Author(s) -
MASUDA Hitoshi,
YANO Masataka,
ICHIYANAGI Nobutaka,
KIHARA Kazunori
Publication year - 2009
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/j.1757-5672.2009.00033.x
Subject(s) - arginase , nitric oxide , urothelium , forebrain , central nervous system , inhibitory postsynaptic potential , urination , endogeny , nitric oxide synthase , neuroscience , chemistry , spinal cord , reflex , urinary system , endocrinology , pharmacology , medicine , arginine , biology , biochemistry , amino acid
Nitric oxide (NO) pathway is of critical importance in the physiological regulation of micturition reflex. NO released from urothelium and suburothelium depresses afferent micturition pathway, while in the central nervous system NO has dual effects on afferent pathway; i.e, excitatory effect in the spinal cord and brain stem and inhibitory effect in the forebrain. Elevated endogenous NO synthase (NOS) inhibitors and increased arginase activity in the lower urinary tracts contribute to NO deficiency, leading to impairement of NO‐mediated relaxations and excitation of different pathway. Therefore, manipulation of endogenous NOS inhibitors and arginase may be new targets of micturition disorders.