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Localized Effects of Antimuscarinics in the Bladder
Author(s) -
KIM YongTae,
CHANCELLOR Michale B.,
TYAGI Pradeep,
YOSHIMURA Naoki,
MASUDA Hitoshi,
KIM Dae Kyung,
KWON Don Deuk,
CHUANG Yaochi
Publication year - 2009
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/j.1757-5672.2009.00030.x
Subject(s) - urothelium , muscarinic acetylcholine receptor , urinary bladder , urology , anticholinergic , overactive bladder , urine , medicine , pharmacology , receptor , chemistry , endocrinology , pathology , alternative medicine
Following oral administration, each antimuscarinic agent exerts a range of effects on the bladder urothelium due to a variety of pharmacological activity from the parent compound, inactive, or active metabolites following excretion into the bladder, as studied in a rat detrusor overactivity model. Differences in localized bladder effects exist among antimuscarinic agents, and the agents excreted into the urine with substantial activity might be more effective for treating bladder overactivity because of this localized effect, in addition to the systemic effects on muscarinic receptors in the bladder wall.