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Role of Ion Channels in the Bladder
Author(s) -
KIM Duk Yoon
Publication year - 2009
Publication title -
luts: lower urinary tract symptoms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.451
H-Index - 15
eISSN - 1757-5672
pISSN - 1757-5664
DOI - 10.1111/j.1757-5672.2009.00029.x
Subject(s) - overactive bladder , muscarinic acetylcholine receptor , carbachol , urology , urinary bladder , excitatory postsynaptic potential , medicine , acetylcholine , receptor , pharmacology , endocrinology , chemistry , pathology , alternative medicine
Overactive bladder is frequently caused by alterations in neuronal and urinary bladder smooth muscle (UBSM) electrical activity. The main therapy that is used to treat overactive bladder is muscarinic receptor blockers, which can reduce the coupling of excitatory acetylcholine to UBSM muscarinic receptors. However, most antimuscarinics have side‐effects, such as dry mouth and constipation. The identification of novel targets for the development of better therapies for overactive bladder is of great interest and a high research priority. The modulation of ion channels involved in neuronal and UBSM electrical activity has demonstrated effectiveness in altering in vivo bladder function and are promising new targets in the treatment of overactive bladder syndrome.