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Risk factors for drug resistance in pulmonary tuberculosis inpatients
Author(s) -
Yang Xiaoyan,
Li Youping,
Wen Xianmin,
Wu Guihui,
Li Xi
Publication year - 2010
Publication title -
journal of evidence‐based medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 22
ISSN - 1756-5391
DOI - 10.1111/j.1756-5391.2010.01088.x
Subject(s) - medicine , odds ratio , confidence interval , drug resistance , logistic regression , medical record , tuberculosis , drug resistant tuberculosis , risk factor , pulmonary tuberculosis , retrospective cohort study , drug , mycobacterium tuberculosis , pharmacology , pathology , microbiology and biotechnology , biology
Objective To analyze risk factors for drug resistance in pulmonary tuberculosis (PTB) inpatients. Methods Medical records of PTB inpatients in Chengdu Tuberculosis Hospital (CTH) from 2005 to 2007 were investigated retrospectively. A logistic regression model was used to analyze data. Results A total of 330 records were included in the analysis. A history of tuberculosis treatment was associated with drug resistance with odds ratio (OR) 16.79 and 95% confidence interval (95% CI) [10.14, 27.80] for all patients. Among new patients, the significant risk factor was duration of illness (OR 0.27, 95% CI [0.16, 0.46]), and for previously treated patients, risk factors included age (OR 0.96, 95% CI [0.93, 0.99]), improper initial chemotherapy (OR 3.85, 95% CI [1.59, 10.00]), and improper handling by medical staff (OR 3.44, 95% CI [1.32, 8.96]). Conclusions A history of drug treatment is associated with drug resistance among PTB inpatients. Initial resistance becomes increasingly serious till 2007. To minimize the development of resistance, more personalized treatment and supervision should be used, and better training for medical staff is needed.