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Urine s VCAM ‐1 and s ICAM ‐1 levels are elevated in lupus nephritis
Author(s) -
Howe Hwee Siew,
Kong Kok Ooi,
Thong Bernard YH,
Law Weng Giap,
Chia Faith L. A.,
Lian Tsui Yee,
Lau Tang Ching,
Chng Hiok Hee,
Leung Bernard P. L.
Publication year - 2012
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/j.1756-185x.2012.01720.x
Subject(s) - lupus nephritis , medicine , urine , urinary system , nephritis , systemic lupus erythematosus , immunology , creatinine , proteinuria , gastroenterology , kidney , endocrinology , disease
Aim We sought to evaluate the relationship of urine levels of soluble cellular adhesion molecules s VCAM ‐1 (vascular) and s ICAM ‐1 (intercellular) in systemic lupus erythematosus ( SLE ) patients with or without lupus nephritis, and to explore their correlation with renal disease activity. Methods Paired serum and urine samples of 121 A sian SLE patients, and urine samples of 19 normal healthy controls were collected. Demographic data, disease activity and damage scores, and selected laboratory parameters, including levels of anti‐double stranded DNA antibody, complements C 3, C 4, and creatinine were captured. Renal disease activity was scored with renal SLE A ctivity M easure revised (r SLAM ‐ R ). Serum and urine s VCAM ‐1 and s ICAM ‐1 levels were assayed by enzyme‐linked immunosorbent assay. Results Urinary s VCAM ‐1 and s ICAM ‐1 were elevated in SLE patients compared to controls. Significantly higher levels of urine s VCAM ‐1 found in patients with active lupus nephritis correlated with r SLAM ‐ R . In addtion, significantly more patients with active lupus nephritis had detectable levels of urine s ICAM ‐1, but no correlation with renal activity was observed. Conclusion Urinary s VCAM ‐1 may serve as a potential biomarker for early diagnosis of lupus nephritis as levels correlated with even mild abnormalities of urine sediment. In addition, both urine s VCAM ‐1 and s ICAM ‐1 levels may be useful in identifying patients at risk of lupus nephritis.