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Behcet’s disease in Iran: analysis of 6500 cases
Author(s) -
DAVATCHI Fereydoun,
SHAHRAM Farhad,
CHAMSDAVATCHI Cheyda,
SHAMS Hormoz,
NADJI Abdolhadi,
AKHLAGHI Massoomeh,
FAEZI Tahereh,
GHODSI Zahra,
LARIMI Roghieh,
ASHOFTEH Farima,
ABDOLLAHI Bahar SADEGHI
Publication year - 2010
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/j.1756-185x.2010.01549.x
Subject(s) - medicine , erythema nodosum , behcet's disease , retinal vasculitis , dermatology , pathergy , epididymitis , oligoarthritis , mucocutaneous zone , vasculitis , aseptic meningitis , ankylosing spondylitis , erythrocyte sedimentation rate , surgery , arthritis , disease , polyarthritis , meningitis
Objective: To identify the clinical picture of Behcet’s disease in a large cohort of patients (6500) in Iran, over a period of 35 years, and compare them with other large series from around the world. Methods: Patients with Behcet’s disease from all over Iran were seen in the Behcet’s Disease Research Unit by a multidisciplinary team (rheumatologists, dermatologists, and ophthalmologists). Diagnosis was based on ‘expert opinion’. Data were collected on a standardized data sheet (105 items), and stored in an electronic database. Data were updated at each follow‐up. Results: Male to female ratio was 1.22 : 1.00. The mean age at onset was 26 years ± 11.3. The frequency of symptoms were: oral aphthosis 97.3%, genital aphthosis 64.6%, skin manifestations 64.9% (pseudofolliculitis 54.5%, erythema nodosum 22.5%, other lesions 7%), pathergy phenomenon 52.5%, ophthalmologic manifes‐tations 56.8% (anterior uveitis 41.2%, posterior uveitis 44.9%, retinal vasculitis 32.1%), joint manifestations 37.4% (arthralgia 17.2%, monoarticular arthritis 7.6%, oligoarthritis 16.8%, ankylosing spondylitis 2%), neurological manifestations 3.8% (central manifestations 3.5%, mononeuritis multiplex 0.3%), gastrointestinal manifestations 7.4%, vascular involvement 8.3% (phlebitis 5.7%, superficial phlebitis 2.2%, large vein thrombosis 1.1%, arterial thrombosis 0.154%, aneurysm 0.5%), epididymitis 4.7%, cardiac involvement 0.6%, and pulmonary involvement 0.9%. Sedimentation rate was normal in 46.5% of patients. Abnormal urine sediment was detected in 12.2%. HLA‐B5 was present in 53.3% and HLA‐B51 in 47.9% of patients. Conclusion: Behcet’s disease is mainly seen in young people. The most frequent symptoms are mucocutaneous, ocular and joint manifestations. Comparison with large series did not show major differences.