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Utilisation of plasma exchange in the treatment of digital infarcts in Wegener’s granulomatosis
Author(s) -
LEUNG Albert,
SUNG Chee B.,
KOTHARI Gargi,
MACK Christopher,
FONG Christopher
Publication year - 2010
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/j.1756-185x.2010.01541.x
Subject(s) - medicine , vasospasm , vasculitis , cyclophosphamide , embolization , refractory (planetary science) , anti neutrophil cytoplasmic antibody , pathology , cardiology , radiology , chemotherapy , disease , physics , astrobiology , subarachnoid hemorrhage
Digital ischemia is a rare manifestation of Wegener’s granulomatosis (WG) with previous management approaches based on the hypotheses of thromboembolic phenomenon and vasospasm. WG is an autoimmune, antineutrophil cytoplasmic antibody‐predominant small‐to‐medium‐vessel necrotising vasculitis which mainly affects the pulmonary–renal system. We report on a patient with WG presenting with digital infarction. We successfully treated this patient who had digital infarcts refractory to cyclophosphamide, steroids and vasodilator agents, with plasma exchange.