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Churg–Strauss syndrome: a retrospective study of 11 cases from a single center in Japan
Author(s) -
HORAI Yoshiro,
MIYAMURA Tomoya,
HIRATA Akie,
NAKAMURA Masataka,
TAKAHAMA Soichiro,
ANDO Hitoshi,
MINAMI Rumi,
YAMAMOTO Masahiro,
SUEMATSU Eiichi
Publication year - 2010
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/j.1756-185x.2010.01479.x
Subject(s) - medicine , etiology , eosinophilia , vasculitis , myeloperoxidase , medical record , anti neutrophil cytoplasmic antibody , asthma , gastroenterology , inflammation , disease
Objective: To investigate the clinical characteristics of patients with Churg–Strauss syndrome (CSS), including symptoms, blood chemistry and immunological findings. Patients and methods: We retrospectively investigated the records of 11 patients (six female and five male) with CSS admitted to our hospital from September 2003 to October 2009. Results: Eight patients had preceding symptoms including bronchial asthma and allergic rhinitis. Seven patients showed eosinophilia. Nine patients had mononeuritis multiplex. Positive findings of myeloperoxidase‐antineutrophil cytoplasmic antibody (MPO‐ANCA) were found in five patients. Neither clinical manifestations nor laboratory findings were correlated with positivity for MPO‐ANCA. However, the MPO‐ANCA‐positive group showed a higher level of blood urea nitrogen and proteinuria than those negative for MPO‐ANCA. Ten patients recovered after starting steroid or immunosuppressive therapy, although one patient died of unknown etiology. Conclusion: Although general assessments based on various factors such as medical history, clinical manifestation and laboratory studies are indispensable in CSS, MPO‐ANCA might be useful as a predictor of renal dysfunction in patients with CSS.