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Reduced bone density in individuals with severe hemophilia B
Author(s) -
MANSOURITORGHABEH Hassan,
REZAIEYAZDI Zahra,
SAADATI Nayyereh,
SAGHAFI Masoud,
MIRFEIZI Zahra,
REZAI Javad
Publication year - 2009
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/j.1756-185x.2009.01394.x
Subject(s) - medicine , bone mineral , bone density , coagulation , case control study , femur , complication , gastroenterology , pediatrics , surgery , osteoporosis
Aim: The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case‐control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX). Methods: In our case‐control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age‐ and sex‐matched control group results. Results: Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (–0.34 ± 0.97) and femur (–0.82 ± 1.37) regions, compared to the control group (0.84 ± 0.53 and 1.02 ± 1.04 respectively; P ‐value = 0.000 and 0.000). Conclusion: The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.