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TNF‐α polymorphisms in Korean adult‐onset Still's disease patients
Author(s) -
SUNG YoonKyoung,
SEONG SangSeokg,
WOO JinHyun,
LEE MyungHo,
CHUNG WonTae,
CHOE JeongYoon,
YOO DaeHyun
Publication year - 2008
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/j.1756-185x.2008.00351.x
Subject(s) - haplotype , adult onset still's disease , medicine , genotype , allele , restriction fragment length polymorphism , pathogenesis , polymorphism (computer science) , disease , polymerase chain reaction , tumor necrosis factor alpha , allele frequency , genotype frequency , immunology , genetics , gene , biology
Aim: To investigate the role of TNF‐α promoter polymorphisms in the pathogenesis of Korean adult‐onset Still's disease (AOSD) patients. Methods: DNA was isolated from blood samples collected from 58 patients with AOSD meeting Yamaguchi's criteria and 105 healthy controls. TNF‐α promoter polymorphisms at positions –1013, –863, –857, –308 were analysed by polymerase chain reaction‐restriction fragment length polymorphism method. Genotype, allele, and estimated haplotype frequencies were compared between the AOSD group and controls. Results: The genotype, allele distributions, and estimated haplotype frequencies of the TNF‐α polymorphism between AOSD patients and controls were not significantly different. In addition, TNF‐α polymorphisms did not appear to have an effect on the disease course of the Korean AOSD patients. Conclusion: Genetic polymorphisms of TNF‐α do not play a significant role in the development or in their course of Korean AOSD patients.