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THE DIABETIC CKD PATIENT—A MAJOR CARDIOVASCULAR CHALLENGE
Author(s) -
Van Der Meer Irene M.,
Ruggenenti Piero,
Remuzzi Giuseppe
Publication year - 2010
Publication title -
journal of renal care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.381
H-Index - 27
eISSN - 1755-6686
pISSN - 1755-6678
DOI - 10.1111/j.1755-6686.2010.00165.x
Subject(s) - medicine , albuminuria , kidney disease , intensive care medicine , disease , diabetes mellitus , population , incidence (geometry) , clinical trial , psychological intervention , renal replacement therapy , physical therapy , endocrinology , environmental health , physics , psychiatry , optics
SUMMARY The diabetic patient with chronic kidney disease (CKD) is at very high risk of cardiovascular disease (CVD). Primary and secondary CVD prevention is of major importance and should be targeted at both traditional cardiovascular risk factors and risk factors specific for patients with CKD, such as albuminuria, anaemia and CKD—mineral and bone disorder. However, treatment goals have largely been derived from clinical trials including patients with no or only mild CKD and may not be generalisable to patients with advanced renal disease. Moreover, in patients on renal replacement therapy, the association between traditional CVD risk factors and the incidence of CVD may be reversed, and pharmaceutical interventions that are beneficial in the general population may be ineffective or even harmful in this high‐risk population. Those involved in the delivery of care to patients with diabetes and CKD need to be aware of these issues and should adopt an individualised approach to treatment.