Open AccessA Modified Model of Middle Cerebral Artery Electrocoagulation in Mice
Author(s) -
Ma Jing,
Peng Cheng,
Guo Wei,
Dong YaFen,
Dong XiaoHui,
Sun Xin,
Xie HeHui
Publication year - 2012
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/j.1755-5949.2012.00370.x
Subject(s) - medicine , occlusion , middle cerebral artery , electrocoagulation , ischemia , cerebral infarction , stroke (engine) , infarction , animal model , anesthesia , chloral hydrate , surgery , cardiology , myocardial infarction , mechanical engineering , engineering
Ischemic stroke is a devastating disease that represents the second leading cause of death worldwide [1]. As ischemic stroke in patients usually results from a thrombotic or embolic occlusion in a major cerebral artery, most often the middle cerebral artery (MCA), experimental focal cerebral ischemia models have been developed to mimic human stroke and serve as an indispensable tool in the stroke research field [2]. Two procedures, microsurgical direct occlusion of the MCA by electrocoagulation (electrocoagulation model) and intraluminal thread occlusion of the MCA (intraluminal occlusion model), are