Open AccessAcupuncture Stimulation on GB 34 Activates Neural Responses Associated with P arkinson's Disease
Author(s) -
Yeo Sujung,
Lim Sabina,
Choe IlHwan,
Choi YeongGon,
Chung KyungCheon,
Jahng GeonHo,
Kim SungHoon
Publication year - 2012
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/j.1755-5949.2012.00363.x
Subject(s) - putamen , acupuncture , substantia nigra , medicine , functional magnetic resonance imaging , parkinson's disease , thalamus , deep brain stimulation , stimulation , neuroscience , disease , psychology , pathology , alternative medicine
Summary Background Parkinson's disease (PD) is a degenerative brain disorder that is caused by neural defects in the substantia nigra. Numerous studies have reported that acupuncture treatment on GB 34 (Yanglingquan) leads to significant improvements in patients with PD and in PD animal models. Studies using functional magnetic resonance imaging ( fMRI ) have shown that patients with PD , compared to healthy participants, have lower neural responses in extensive brain regions including the putamen, thalamus, and the supplementary motor area. Objective This study investigated the reported association between acupuncture point GB 34 and PD . Methods Using fMRI , neural responses of 12 patients with PD and 12 healthy participants were examined before and after acupuncture stimulation. Results Acupuncture stimulation increased neural responses in regions including the substantia nigra, caudate, thalamus, and putamen, which are impaired caused by PD . Conclusions Areas associated with PD were activated by the acupuncture stimulation on GB 34. This shows that acupuncture treatment on GB 34 may be effective in improving the symptoms of PD . Although more randomized controlled trials on the topic will be needed, this study shows that acupuncture may be helpful in the treatment of symptoms involving PD .